Scientists at Columbia University, led by Nobel laureate Eric Kandel (Eric Kandel) found that the hormone osteocalcin, which is produced by bone cells, improves memory in the aging brain.
This was reported in a press release on MedicalXpress, reports Sotsportal.
In previous studies, biologists have shown that physical exercise releases the RbAp48 protein, which prevents the onset of senile dementia. RbAp48 is involved in the formation of chromatin – a complex of DNA, RNA and other various proteins. At the same time, the suppression of the mouse gene encoding the compound leads to a deterioration in the cognitive abilities of young rodents, similar to that observed in old animals.
In the new work, scientists have demonstrated that RbAp48 interacts with osteocalcin. RbAp48 controls the activity of genes encoding the neurotrophic factor of the brain BDNF and the protein receptor GPR158. The work of these compounds important to memory, in turn, depends on osteocalcin.
According to the researchers, even a small physical activity, such as walking, helps release osteocalcin and RbAp48, which reduces the risk of developing senile dementia.